Table 1.

Vaccine responses

Healthy controlLeukemiaLymphomaMultiple myelomaAll patients
Total individuals69157173221551
Vaccine subtypeBNT162b258 (84.1%)105136172413 (75%)
mRNA-127311 (15.9%)523749138 (25%)
SARS-CoV-2 spike IgG antibody response: Prior COVID-19 illness1 mo seropositive rate8/9 (88.9%)1/1 (100%)5/5 (100%)6/6 (100%)12/12 (100%)
1 mo Ab titer (AU/mL): mean ± SD16,881 ± 8,302719.9 ± 013,748 ± 11,79221,881 ± 4,98416,729 ± 10,182
1 mo Ab titer (AU/mL): median (IQR)16,850 (12,763–24,672)719.9 (719.9–719.9)15,536 (1,602–25,000)25,000 (16,607–25,000)21,286 (5,787–25,000)
3 mo seropositive rate9/9 (100%)5/7 (71.4%)10/10 (100%)10/11 (90.9%)25/28 (89.3%)
3 mo Ab titer (AU/mL): mean ± SD17,737 ± 6,32714,617 ± 12,97319,003 ± 9,00617,817 ± 8,49217,441 ± 9,704
3 mo Ab titer (AU/mL): median (IQR)16,748 (11,566–25,000)25,000 (4.9–25,000)24,798 (12,669–25,000)21,749 (11,244–25,000)24,798 (10,604–25,000)
SARS-CoV-2 spike IgG antibody response: No prior COVID-19 illness1 mo seropositive rate59/59 (100%)10/34 (29.4%)18/38 (47.4%)58/95 (61.1%)86/167 (51.5%)
1 mo Ab titer (AU/mL): mean ± SD2,620 ± 5,1041,137 ± 4,5981,481 ± 4,0151,716 ± 4,8891,545 ± 4,624
1 mo Ab titer (AU/mL): median (IQR)886.2 (502.3–2,240)4.5 (1.8–86.33)46 (4.9–329.9)96.6 (8.3–571.4)55.7 (4–465.7)
3 mo seropositive rate54/54 (100%)73/131 (55.7%)74/132 (56.1%)167/193 (86.5%)314/456 (68.9%)
3 mo Ab titer (AU/mL): mean ± SD7,656 ± 4,7013,827 ± 7,2174,241 ± 7,7524,176 ± 6,7754,095 ± 7,182
3 mo Ab titer (AU/mL): median (IQR)7,720 (3,885–9,746)187 (5–3,632)127 (6.5–3,592)1,218 (180.4–4,424)517.7 (18.2–3,779)
Healthy controlPatients with hematologic malignancies
Neutralizing antibody1 mo positive inhibition55/59 (93.2%)21/80 (26.3%)
1 mo: mean % inhibition ± SD62.8 ± 20.322.8 ± 26.3
1 mo: median % inhibition (IQR)63.6 (51.3–78.4)11.3 (4.9–30.6)
3 mo positive inhibition21/21 (100%)17/39 (43.6%)
3 mo: mean % inhibition ± SD94 ± 4.236 ± 40.4
3 mo: median % inhibition (IQR)95.6 (93.8–95.9)9.3 (1–86.7)
  • Abbreviations: Ab, antibody; AU/mL, artificial units/milliliter; IQR, interquartile range; mo, month; SD, standard deviation.