In This Issue | Free Article
Blood Cancer Discov January 1 2021 2 (1) 1-2; DOI:10.1158/2643-3249.BCD-ITI2-1
Proinflammatory lipid receptor S1RP3 drives myeloid differentiation in HSC as well as LSC and marks a specific subtype of less-primitive LSC, serving as a promising biomarker and therapeutic target for AML.
Longitudinal DNA methylome landscapes of normal, premalignant, and CLL cells reveal reprogramming at the earliest premalignant precursor stage, which is retained throughout clonal evolution and therapeutic interventions.
Myd88/BCL2-driven mouse model mimics the transcriptomic and morphologic features of human ABCDLBCL and demonstrates that combination therapy blocking both BCL2 and PD-1 displays superior antilymphoma ability.
Noncoding genetic region PE is a conserved hematopoietic-specific PTEN long-distance enhancer. Its deletion accelerates Notch-driven leukemia in mice and is recurrent in human T-ALL.