Table of Contents

Research Articles

• Research Articles | Free Article

  COVID-19 Infections and Clinical Outcomes in Patients with Multiple Myeloma in New York City: A Cohort Study from Five Academic Centers

  Malin Hultcrantz, Joshua Richter, Cara A. Rosenbaum, Dhwani Patel, Eric L. Smith, Neha Korde, Sydney X. Lu, Sham Mailankody, Urvi A. Shah, Alexander M. Lesokhin, Hani Hassoun, Carlyn Tan, Francesco Maura, Andriy Derkach, Benjamin Diamond, Adriana Rossi, Roger N. Pearse, Deepu Madduri, Ajai Chari, David Kaminetzky, Marc J. Braunstein, Christian Gordillo, Ran Reshef, Ying Taur, Faith E. Davies, Sundar Jagannath, Ruben Niesvizky, Suzanne Lentzsch, Gareth J. Morgan and Ola Landgren

  Blood Cancer Discov November 1 2020 1 (3) 234-243; DOI:10.1158/2643-3230.BCD-20-0102

  
  

  Medical records uncover clinical and demographic characteristics associated with severity of COVID-19 in a large multicenter cohort of patients with multiple myeloma.
• Research Articles | Free Article

  PRPS-ST: A Protocol-Agnostic Self-training Method for Gene Expression–Based Classification of Blood Cancers

  Aixiang Jiang, Laura K. Hilton, Jeffrey Tang, Christopher K. Rushton, Bruno M. Grande, David W. Scott and Ryan D. Morin

  Blood Cancer Discov November 1 2020 1 (3) 244-257; DOI:10.1158/2643-3230.BCD-20-0076

  
  

  An algorithm overcomes the problem of gene expression-based classification portability across different methods and batches, improving lymphoma subtyping accuracy and enabling consolidation of patient classification from multiple sources.
• Research Articles | Free Article

  Revealing the Impact of Structural Variants in Multiple Myeloma

  Even H. Rustad, Venkata D. Yellapantula, Dominik Glodzik, Kylee H. Maclachlan, Benjamin Diamond, Eileen M. Boyle, Cody Ashby, Patrick Blaney, Gunes Gundem, Malin Hultcrantz, Daniel Leongamornlert, Nicos Angelopoulos, Luca Agnelli, Daniel Auclair, Yanming Zhang, Ahmet Dogan, Niccolò Bolli, Elli Papaemmanuil, Kenneth C. Anderson, Philippe Moreau, Hervé Avet-Loiseau, Nikhil C. Munshi, Jonathan J. Keats, Peter J. Campbell, Gareth J. Morgan, Ola Landgren and Francesco Maura

  Blood Cancer Discov November 1 2020 1 (3) 258-273; DOI:10.1158/2643-3230.BCD-20-0132

  
  

  Genome-wide analysis of structural variants and gene expression of a large well-annotated clinical cohort reveals new drivers and widespread impact of complex rearrangements on multiple myeloma development and outcomes.
• Research Articles | Free Article

  Aging of Preleukemic Thymocytes Drives CpG Island Hypermethylation in T-cell Acute Lymphoblastic Leukemia

  Juliette Roels, Morgan Thénoz, Bronisława Szarzyńska, Mattias Landfors, Stien De Coninck, Lisa Demoen, Lien Provez, Anna Kuchmiy, Steven Strubbe, Lindy Reunes, Tim Pieters, Filip Matthijssens, Wouter Van Loocke, Büşra Erarslan-Uysal, Paulina Richter-Pechańska, Ken Declerck, Tim Lammens, Barbara De Moerloose, Dieter Deforce, Filip Van Nieuwerburgh, Laurence C. Cheung, Rishi S. Kotecha, Marc R. Mansour, Bart Ghesquière, Guy Van Camp, Wim Vanden Berghe, Jerzy R. Kowalczyk, Tomasz Szczepański, Utpal P. Davé, Andreas E. Kulozik, Steven Goossens, David J. Curtis, Tom Taghon, Małgorzata Dawidowska, Sofie Degerman and Pieter Van Vlierberghe

  Blood Cancer Discov November 1 2020 1 (3) 274-289; DOI:10.1158/2643-3230.BCD-20-0059

  
  

  DNA methylation landscape of T-ALL identifies a developmental age signature suggesting long-lived thymocyte as a preneoplastic cell of origin in a subset of T-ALL.