Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Collections
      • Myeloma
      • Highlights from BCD
      • COVID-19 & Cancer Resource Center
  • For Authors
    • Information for Authors
    • Author Services
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Blood Cancer Discovery
Blood Cancer Discovery
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Collections
      • Myeloma
      • Highlights from BCD
      • COVID-19 & Cancer Resource Center
  • For Authors
    • Information for Authors
    • Author Services
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

About the Cover

Cover image

Cover image expansion

The labs of John Dick, Roland Kuiper, Charles Mullighan join forces to characterize mechanisms of relapse in a large cohort of pediatric ALL through the power of high-resolution genomics. They report that in most cases, relapse-associated mutations can be traced to a subclone already present at diagnosis. Taken from treatment-naïve patients, these subclones display drug resistance in mouse xenografts. The relapse-fated subclones carry genomic alterations known to drive resistance, and expand in patients following therapy. Clones persisting through serial relapses display hypermutation suggestive of increased immunogenicity. Genomic patterns revealed in this analysis may help identifying personalized therapies least prone to relapse. For details, please see the article by Waanders and colleagues on page 96 and a joint publication in the April issue of Cancer Discovery.

Back to top
Next
Blood Cancer Discovery: 1 (1)
July 2020
Volume 1, Issue 1
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Editorial Board (PDF)

Sign up for alerts

Advertisement
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • OnlineFirst
  • Current Issue

Info For

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Blood Cancer Discovery

  • About the Journal
  • Editors
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Blood Cancer Discovery
eISSN: 2643-3249
ISSN: 2643-3230

Advertisement