Inaugural Article

Research Article | Free Article

Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia
Esmé Waanders, Zhaohui Gu, Stephanie M. Dobson, Željko Antić, Jeremy Chase Crawford, Xiaotu Ma, Michael N. Edmonson, Debbie Payne-Turner, Maartje van de Vorst, Marjolijn C.J. Jongmans, Irina McGuire, Xin Zhou, Jian Wang, Lei Shi, Stanley Pounds, Deqing Pei, Cheng Cheng, Guangchun Song, Yiping Fan, Ying Shao, Michael Rusch, Kelly McCastlain, Jiangyan Yu, Ruben van Boxtel, Francis Blokzijl, Ilaria Iacobucci, Kathryn G. Roberts, Ji Wen, Gang Wu, Jing Ma, John Easton, Geoffrey Neale, Scott R. Olsen, Kim E. Nichols, Ching-Hon Pui, Jinghui Zhang, William E. Evans, Mary V. Relling, Jun J. Yang, Paul G. Thomas, John E. Dick, Roland P. Kuiper, and Charles G. Mullighan
Blood Cancer Discov January 9 2020 DOI:10.1158/0008-5472.BCD-19-0041

Reports the landscape of mutations present in pediatric ALL and how this landscape changes during treatment, leading to relapse.

Blood Cancer Discovery will provide a critical outlet for high-impact basic, translational, and clinical research on all disease subtypes of leukemia, lymphoma, myeloma, and associated diseases. Studies published in Blood Cancer Discovery will describe the mechanisms underlying disease biology; diagnostic and therapeutic development; and the translation of these data into clinic trials.