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- Research Articles | Free ArticleStephanie Z. Xie, Kerstin B. Kaufmann, Weijia Wang, Michelle Chan-Seng-Yue, Olga I. Gan, Elisa Laurenti, Laura Garcia-Prat, Shin-ichiro Takayanagi, Stanley W.K. Ng, ChangJiang Xu, Andy G.X. Zeng, Liqing Jin, Jessica McLeod, Elvin Wagenblast, Amanda Mitchell, James A. Kennedy, Qiang Liu, Héléna Boutzen, Melissa Kleinau, Joseph Jargstorf, Gareth Holmes, Yang Zhang, Veronique Voisin, Gary D. Bader, Jean C.Y. Wang, Yusuf A. Hannun, Chiara Luberto, Timm Schroeder, Mark D. Minden and John E. DickBlood Cancer Discov January 1 2021 2 (1) 32-53; DOI:10.1158/2643-3230.BCD-20-0155
Proinflammatory lipid receptor S1RP3 drives myeloid differentiation in HSC as well as LSC and marks a specific subtype of less-primitive LSC, serving as a promising biomarker and therapeutic target for AML.
- Research Articles | Free ArticleHelene Kretzmer, Anat Biran, Noelia Purroy, Camilla K. Lemvigh, Kendell Clement, Michaela Gruber, Hongcang Gu, Laura Rassenti, Arman W. Mohammad, Connie Lesnick, Susan L. Slager, Esteban Braggio, Tait D. Shanafelt, Neil E. Kay, Stacey M. Fernandes, Jennifer R. Brown, Lili Wang, Shuqiang Li, Kenneth J. Livak, Donna S. Neuberg, Sven Klages, Bernd Timmermann, Thomas J. Kipps, Elias Campo, Andreas Gnirke, Catherine J. Wu and Alexander MeissnerBlood Cancer Discov January 1 2021 2 (1) 54-69; DOI:10.1158/2643-3230.BCD-19-0058
Longitudinal DNA methylome landscapes of normal, premalignant, and CLL cells reveal reprogramming at the earliest premalignant precursor stage, which is retained throughout clonal evolution and therapeutic interventions.
- Review | Free ArticleValentina Cordo', Jordy C.G. van der Zwet, Kirsten Canté-Barrett, Rob Pieters and Jules P.P. MeijerinkBlood Cancer Discov January 1 2021 2 (1) 19-31; DOI:10.1158/2643-3230.BCD-20-0093
- Research Articles | Free ArticleLuca Tottone, Olga Lancho, Jui-Wan Loh, Amartya Singh, Shunsuke Kimura, Juliette Roels, Anna Kuchmiy, Steven Strubbe, Matthew A. Lawlor, Victoria da Silva-Diz, Shirley Luo, Stéphanie Gachet, Carlos A. García-Prieto, Rico Hagelaar, Manel Esteller, Jules P.P. Meijerink, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Charles G. Mullighan, Hossein Khiabanian, Pedro P. Rocha and Daniel HerranzBlood Cancer Discov January 1 2021 2 (1) 92-109; DOI:10.1158/2643-3230.BCD-20-0201
Noncoding genetic region PE is a conserved hematopoietic-specific PTEN long-distance enhancer. Its deletion accelerates Notch-driven leukemia in mice and is recurrent in human T-ALL.
- Research Articles | Free ArticleRuth Flümann, Tim Rehkämper, Pascal Nieper, Pauline Pfeiffer, Alessandra Holzem, Sebastian Klein, Sanil Bhatia, Moritz Kochanek, Ilmars Kisis, Benedikt W. Pelzer, Heinz Ahlert, Julia Hauer, Alexandra da Palma Guerreiro, Jeremy A. Ryan, Maurice Reimann, Arina Riabinska, Janica Wiederstein, Marcus Krüger, Martina Deckert, Janine Altmüller, Andreas R. Klatt, Lukas P. Frenzel, Laura Pasqualucci, Wendy Béguelin, Ari M. Melnick, Sandrine Sander, Manuel Montesinos-Rongen, Anna Brunn, Philipp Lohneis, Reinhard Büttner, Hamid Kashkar, Arndt Borkhardt, Anthony Letai, Thorsten Persigehl, Martin Peifer, Clemens A. Schmitt, Hans Christian Reinhardt and Gero KnittelBlood Cancer Discov January 1 2021 2 (1) 70-91; DOI:10.1158/2643-3230.BCD-19-0059
Myd88/BCL2-driven mouse model mimics the transcriptomic and morphologic features of human ABCDLBCL and demonstrates that combination therapy blocking both BCL2 and PD-1 displays superior antilymphoma ability.
OnlineFirst Articles
- Patterns of Secondary Resistance after FLT3 InhibitorsAhmad S. Alotaibi, et al.
- MYC and TFEB Control DNA Methylation and Differentiation in AMLXiaoying Wu, Robert N. Eisenman
- Humanized niches support myelodysplastic stem cellsSyed A Mian, et al.
- A TFEB-IDH Epigenetic Circuit Controls AML Cell FateSeongseok Yun, et al.
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- A Tumor Suppressor Enhancer of PTEN in T-cell Development and LeukemiaLast mentioned on Mon Jan 25 2021
- Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cellsLast mentioned on Fri Jan 15 2021
- Revealing the Impact of Structural Variants in Multiple MyelomaLast mentioned on Tue Jan 12 2021
- Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote DifferentiationLast mentioned on Wed Jan 20 2021
- TFEB links MYC signaling to epigenetic control of myeloid differentiation and acute myeloid leukemiaLast mentioned on Sat Jan 23 2021
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