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Blood Cancer Discovery

Blood Cancer Discovery

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The AACR remains fully committed to supporting publishing operations throughout this challenging time, while still remaining flexible and supportive of the author, reviewer, and editor communities that we serve. If you have any questions or concerns, please reach out to a member of the AACR publishing staff.
Please visit the COVID-19 & Cancer Resource Center where COVID-related content is freely available.

 

Watch the latest AACR Virtual Journal Club: Blood Cancer Discovery on COVID-19 and multiple myeloma.

  • Current Cover of Blood Cancer Discovery
    Read the January issue!
    In this issue, Stephanie Xie, John Dick, and colleagues characterize sphingosine-1-phosphate receptor 3 (S1PR3) as a plausible target in AML.
  • Viral Immunity and Vaccines in Hematologic Malignancies
    In Focus
    Read: Viral Immunity and Vaccines in Hematologic Malignancies: Implications for COVID-19, Madhav V. Dhodapkar et al.
  • In Focus
    In Focus
    Read: Cancer and COVID-19: On the Quest for Effective Vaccines, Catherine J. Wu et al.
  • In the Spotlight
    In the Spotlight
    Read: Epigenetic Trajectories of the Premalignant-to-Malignant Transition of Chronic Lymphocytic Leukemia, Davide Rossi.
  • In the Spotlight
    In the Spotlight
    Read: A Novel Function of Sphingolipid Signaling via S1PR3 in Hematopoietic and Leukemic Stem Cells, Toshio Suda et al.
  • 1
  • 2
  • 3
  • 4
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From the Current Issue

  • Research Articles | Free Article
    Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation
    Stephanie Z. Xie, Kerstin B. Kaufmann, Weijia Wang, Michelle Chan-Seng-Yue, Olga I. Gan, Elisa Laurenti, Laura Garcia-Prat, Shin-ichiro Takayanagi, Stanley W.K. Ng, ChangJiang Xu, Andy G.X. Zeng, Liqing Jin, Jessica McLeod, Elvin Wagenblast, Amanda Mitchell, James A. Kennedy, Qiang Liu, Héléna Boutzen, Melissa Kleinau, Joseph Jargstorf, Gareth Holmes, Yang Zhang, Veronique Voisin, Gary D. Bader, Jean C.Y. Wang, Yusuf A. Hannun, Chiara Luberto, Timm Schroeder, Mark D. Minden and John E. Dick
    Blood Cancer Discov January 1 2021 2 (1) 32-53; DOI:10.1158/2643-3230.BCD-20-0155

    Proinflammatory lipid receptor S1RP3 drives myeloid differentiation in HSC as well as LSC and marks a specific subtype of less-primitive LSC, serving as a promising biomarker and therapeutic target for AML.

  • Research Articles | Free Article
    Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy
    Helene Kretzmer, Anat Biran, Noelia Purroy, Camilla K. Lemvigh, Kendell Clement, Michaela Gruber, Hongcang Gu, Laura Rassenti, Arman W. Mohammad, Connie Lesnick, Susan L. Slager, Esteban Braggio, Tait D. Shanafelt, Neil E. Kay, Stacey M. Fernandes, Jennifer R. Brown, Lili Wang, Shuqiang Li, Kenneth J. Livak, Donna S. Neuberg, Sven Klages, Bernd Timmermann, Thomas J. Kipps, Elias Campo, Andreas Gnirke, Catherine J. Wu and Alexander Meissner
    Blood Cancer Discov January 1 2021 2 (1) 54-69; DOI:10.1158/2643-3230.BCD-19-0058

    Longitudinal DNA methylome landscapes of normal, premalignant, and CLL cells reveal reprogramming at the earliest premalignant precursor stage, which is retained throughout clonal evolution and therapeutic interventions.

  • Review | Free Article
    T-cell Acute Lymphoblastic Leukemia: A Roadmap to Targeted Therapies
    Valentina Cordo', Jordy C.G. van der Zwet, Kirsten Canté-Barrett, Rob Pieters and Jules P.P. Meijerink
    Blood Cancer Discov January 1 2021 2 (1) 19-31; DOI:10.1158/2643-3230.BCD-20-0093

  • Research Articles | Free Article
    A Tumor Suppressor Enhancer of PTEN in T-cell Development and Leukemia
    Luca Tottone, Olga Lancho, Jui-Wan Loh, Amartya Singh, Shunsuke Kimura, Juliette Roels, Anna Kuchmiy, Steven Strubbe, Matthew A. Lawlor, Victoria da Silva-Diz, Shirley Luo, Stéphanie Gachet, Carlos A. García-Prieto, Rico Hagelaar, Manel Esteller, Jules P.P. Meijerink, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Charles G. Mullighan, Hossein Khiabanian, Pedro P. Rocha and Daniel Herranz
    Blood Cancer Discov January 1 2021 2 (1) 92-109; DOI:10.1158/2643-3230.BCD-20-0201

    Noncoding genetic region PE is a conserved hematopoietic-specific PTEN long-distance enhancer. Its deletion accelerates Notch-driven leukemia in mice and is recurrent in human T-ALL.

  • Research Articles | Free Article
    An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities
    Ruth Flümann, Tim Rehkämper, Pascal Nieper, Pauline Pfeiffer, Alessandra Holzem, Sebastian Klein, Sanil Bhatia, Moritz Kochanek, Ilmars Kisis, Benedikt W. Pelzer, Heinz Ahlert, Julia Hauer, Alexandra da Palma Guerreiro, Jeremy A. Ryan, Maurice Reimann, Arina Riabinska, Janica Wiederstein, Marcus Krüger, Martina Deckert, Janine Altmüller, Andreas R. Klatt, Lukas P. Frenzel, Laura Pasqualucci, Wendy Béguelin, Ari M. Melnick, Sandrine Sander, Manuel Montesinos-Rongen, Anna Brunn, Philipp Lohneis, Reinhard Büttner, Hamid Kashkar, Arndt Borkhardt, Anthony Letai, Thorsten Persigehl, Martin Peifer, Clemens A. Schmitt, Hans Christian Reinhardt and Gero Knittel
    Blood Cancer Discov January 1 2021 2 (1) 70-91; DOI:10.1158/2643-3230.BCD-19-0059

    Myd88/BCL2-driven mouse model mimics the transcriptomic and morphologic features of human ABCDLBCL and demonstrates that combination therapy blocking both BCL2 and PD-1 displays superior antilymphoma ability.


OnlineFirst Articles

  • Patterns of Secondary Resistance after FLT3 Inhibitors
    Ahmad S. Alotaibi, et al.
  • MYC and TFEB Control DNA Methylation and Differentiation in AML
    Xiaoying Wu, Robert N. Eisenman
  • Humanized niches support myelodysplastic stem cells
    Syed A Mian, et al.
  • A TFEB-IDH Epigenetic Circuit Controls AML Cell Fate
    Seongseok Yun, et al.
Load more

Trending - Altmetric

  • Article has an altmetric score of 50
    A Tumor Suppressor Enhancer of PTEN in T-cell Development and Leukemia
    Last mentioned on Mon Jan 25 2021
  • Article has an altmetric score of 10
    Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells
    Last mentioned on Fri Jan 15 2021
  • Article has an altmetric score of 31
    Revealing the Impact of Structural Variants in Multiple Myeloma
    Last mentioned on Tue Jan 12 2021
  • Article has an altmetric score of 7
    Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation
    Last mentioned on Wed Jan 20 2021
  • Article has an altmetric score of 6
    TFEB links MYC signaling to epigenetic control of myeloid differentiation and acute myeloid leukemia
    Last mentioned on Sat Jan 23 2021
  • See more
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Blood Cancer Discovery
eISSN: 2643-3249
ISSN: 2643-3230

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