Published Articles

Research Briefs | Free Article
Gene Expression Profiling of Mediastinal Gray Zone Lymphoma and Its Relationship to Primary Mediastinal B-cell Lymphoma and Classical Hodgkin Lymphoma
Stefania Pittaluga, Alina Nicolae, George W. Wright, Christopher Melani, Mark Roschewski, Seth Steinberg, DaWei Huang, Louis M. Staudt, Elaine S. Jaffe and Wyndham H. Wilson
Blood Cancer Discov March 30 2020 DOI:10.1158/2643-3230.BCD-20-0009

Research Articles | Free Article
Persistence of Drug-resistant Leukemic Stem Cells and Impaired NK-cell Immunity in CML Patients Depend on MIR300 Antiproliferative and PP2A-activating Functions
Giovannino Silvestri, Rossana Trotta, Lorenzo Stramucci, Justin J. Ellis, Jason G. Harb, Paolo Neviani, Shuzhen Wang, Ann-Kathrin Eisfeld, Christopher J. Walker, Bin Zhang, Klara Srutova, Carlo Gambacorti-Passerini, Gabriel Pineda, Catriona H. M. Jamieson, Fabio Stagno, Paolo Vigneri, Georgios Nteliopoulos, Philippa C. May, Alistair G. Reid, Ramiro Garzon, Denis-Claude Roy, Moutuaata M. Moutuou, Martin Guimond, Peter Hokland, Michael W. Deininger, Garrett Fitzgerald, Christopher Harman, Francesco Dazzi, Dragana Milojkovic, Jane F. Apperley, Guido Marcucci, Jianfei Qi, Katerina Machova Polakova, Ying Zou, Xiaoxuan Fan, Maria R. Baer, Bruno Calabretta, and Danilo Perrotti
Blood Cancer Discov March 4 2020 DOI:10.1158/0008-5472.BCD-19-0039

Reports that MIR300 is upregulated by the bone marrow microenvironment, inducing CML LSC quiescence while inhibiting NK cell anti-tumor activity through its anti-proliferative and PP2A-activating functions.

Research Articles | Free Article
Monosomic Loss of MIR15A/MIR16-1 Is a Driver of Multiple Myeloma Proliferation and Disease Progression
Marta Chesi, Caleb K. Stein, Victoria M. Garbitt, Meaghen E. Sharik, Yan W. Asmann, Matteo Bergsagel, Daniel L. Riggs, Seth J. Welsh, Erin W. Meermeier, Shaji K. Kumar, Esteban Braggio, and P. Leif Bergsagel
Blood Cancer Discov February 20 2020 DOI:10.1158/0008-5472.BCD-19-0068

Reports that monoallelic deletion of Mir15a/Mir16-1, but not Rb1, accelerates monoclonal gammopathy in mice and the progression of multiple myeloma in both mice and men.

Research Articles | Free Article
Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia
Esmé Waanders, Zhaohui Gu, Stephanie M. Dobson, Željko Antić, Jeremy Chase Crawford, Xiaotu Ma, Michael N. Edmonson, Debbie Payne-Turner, Maartje van de Vorst, Marjolijn C.J. Jongmans, Irina McGuire, Xin Zhou, Jian Wang, Lei Shi, Stanley Pounds, Deqing Pei, Cheng Cheng, Guangchun Song, Yiping Fan, Ying Shao, Michael Rusch, Kelly McCastlain, Jiangyan Yu, Ruben van Boxtel, Francis Blokzijl, Ilaria Iacobucci, Kathryn G. Roberts, Ji Wen, Gang Wu, Jing Ma, John Easton, Geoffrey Neale, Scott R. Olsen, Kim E. Nichols, Ching-Hon Pui, Jinghui Zhang, William E. Evans, Mary V. Relling, Jun J. Yang, Paul G. Thomas, John E. Dick, Roland P. Kuiper, and Charles G. Mullighan
Blood Cancer Discov January 9 2020 DOI:10.1158/0008-5472.BCD-19-0041

Reports the landscape of mutations present in pediatric ALL and how this landscape changes during treatment, leading to relapse.

Blood Cancer Discovery will provide a critical outlet for high-impact basic, translational, and clinical research on all disease subtypes of leukemia, lymphoma, myeloma, and associated diseases. Studies published in Blood Cancer Discovery will describe the mechanisms underlying disease biology; diagnostic and therapeutic development; and the translation of these data into clinic trials.