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From the Current Issue

Research Articles | Free Article

Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation

Stephanie Z. Xie, Kerstin B. Kaufmann, Weijia Wang, Michelle Chan-Seng-Yue, Olga I. Gan, Elisa Laurenti, Laura Garcia-Prat, Shin-ichiro Takayanagi, Stanley W.K. Ng, ChangJiang Xu, Andy G.X. Zeng, Liqing Jin, Jessica McLeod, Elvin Wagenblast, Amanda Mitchell, James A. Kennedy, Qiang Liu, Héléna Boutzen, Melissa Kleinau, Joseph Jargstorf, Gareth Holmes, Yang Zhang, Veronique Voisin, Gary D. Bader, Jean C.Y. Wang, Yusuf A. Hannun, Chiara Luberto, Timm Schroeder, Mark D. Minden and John E. Dick

Blood Cancer Discov January 1 2021 2 (1) 32-53; DOI:10.1158/2643-3230.BCD-20-0155

Proinflammatory lipid receptor S1RP3 drives myeloid differentiation in HSC as well as LSC and marks a specific subtype of less-primitive LSC, serving as a promising biomarker and therapeutic target for AML.
Research Articles | Free Article

Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy

Helene Kretzmer, Anat Biran, Noelia Purroy, Camilla K. Lemvigh, Kendell Clement, Michaela Gruber, Hongcang Gu, Laura Rassenti, Arman W. Mohammad, Connie Lesnick, Susan L. Slager, Esteban Braggio, Tait D. Shanafelt, Neil E. Kay, Stacey M. Fernandes, Jennifer R. Brown, Lili Wang, Shuqiang Li, Kenneth J. Livak, Donna S. Neuberg, Sven Klages, Bernd Timmermann, Thomas J. Kipps, Elias Campo, Andreas Gnirke, Catherine J. Wu and Alexander Meissner

Blood Cancer Discov January 1 2021 2 (1) 54-69; DOI:10.1158/2643-3230.BCD-19-0058

Longitudinal DNA methylome landscapes of normal, premalignant, and CLL cells reveal reprogramming at the earliest premalignant precursor stage, which is retained throughout clonal evolution and therapeutic interventions.
Review | Free Article

T-cell Acute Lymphoblastic Leukemia: A Roadmap to Targeted Therapies

Valentina Cordo', Jordy C.G. van der Zwet, Kirsten Canté-Barrett, Rob Pieters and Jules P.P. Meijerink

Blood Cancer Discov January 1 2021 2 (1) 19-31; DOI:10.1158/2643-3230.BCD-20-0093
Research Articles | Free Article

A Tumor Suppressor Enhancer of PTEN in T-cell Development and Leukemia

Luca Tottone, Olga Lancho, Jui-Wan Loh, Amartya Singh, Shunsuke Kimura, Juliette Roels, Anna Kuchmiy, Steven Strubbe, Matthew A. Lawlor, Victoria da Silva-Diz, Shirley Luo, Stéphanie Gachet, Carlos A. García-Prieto, Rico Hagelaar, Manel Esteller, Jules P.P. Meijerink, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Charles G. Mullighan, Hossein Khiabanian, Pedro P. Rocha and Daniel Herranz

Blood Cancer Discov January 1 2021 2 (1) 92-109; DOI:10.1158/2643-3230.BCD-20-0201

Noncoding genetic region PE is a conserved hematopoietic-specific PTEN long-distance enhancer. Its deletion accelerates Notch-driven leukemia in mice and is recurrent in human T-ALL.
Research Articles | Free Article

An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities

Ruth Flümann, Tim Rehkämper, Pascal Nieper, Pauline Pfeiffer, Alessandra Holzem, Sebastian Klein, Sanil Bhatia, Moritz Kochanek, Ilmars Kisis, Benedikt W. Pelzer, Heinz Ahlert, Julia Hauer, Alexandra da Palma Guerreiro, Jeremy A. Ryan, Maurice Reimann, Arina Riabinska, Janica Wiederstein, Marcus Krüger, Martina Deckert, Janine Altmüller, Andreas R. Klatt, Lukas P. Frenzel, Laura Pasqualucci, Wendy Béguelin, Ari M. Melnick, Sandrine Sander, Manuel Montesinos-Rongen, Anna Brunn, Philipp Lohneis, Reinhard Büttner, Hamid Kashkar, Arndt Borkhardt, Anthony Letai, Thorsten Persigehl, Martin Peifer, Clemens A. Schmitt, Hans Christian Reinhardt and Gero Knittel

Blood Cancer Discov January 1 2021 2 (1) 70-91; DOI:10.1158/2643-3230.BCD-19-0059

Myd88/BCL2-driven mouse model mimics the transcriptomic and morphologic features of human ABCDLBCL and demonstrates that combination therapy blocking both BCL2 and PD-1 displays superior antilymphoma ability.