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AACR Virtual Journal Club: July 15th at 10 AM EDT, featuring John E. Dick, PhD, FRS and Charles G. Mullighan, MBBS (hons), MSc, MD. Register now!

Read the inaugural issue!
In this issue: an editorial on the landscape of blood cancer research, a Q&A with Dr. Carl June, and six research articles including the role of miRNA in NK-mediated immunity and CML stem cells.
Editorial
Read: The Landscape of Blood Cancer Research Today—And Where the Field is Headed
Q&A
Read: Carl June on CAR T cell therapy
Research Article
Read: Cytotoxic Therapy-Induced Effects on Both Hematopoietic and Marrow Stromal Cells Promotes Therapy-Related Myeloid Neoplasms, Angela Stoddart et al.
Review
Read: Epitranscriptomics in hematopoiesis and hematological malignancies, Manel Esteller et al.

From the Current Issue

Research Articles | Free Article

Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia

Esmé Waanders, Zhaohui Gu, Stephanie M. Dobson, Željko Antić, Jeremy Chase Crawford, Xiaotu Ma, Michael N. Edmonson, Debbie Payne-Turner, Maartje van de Vorst, Marjolijn C.J. Jongmans, Irina McGuire, Xin Zhou, Jian Wang, Lei Shi, Stanley Pounds, Deqing Pei, Cheng Cheng, Guangchun Song, Yiping Fan, Ying Shao, Michael Rusch, Kelly McCastlain, Jiangyan Yu, Ruben van Boxtel, Francis Blokzijl, Ilaria Iacobucci, Kathryn G. Roberts, Ji Wen, Gang Wu, Jing Ma, John Easton, Geoffrey Neale, Scott R. Olsen, Kim E. Nichols, Ching-Hon Pui, Jinghui Zhang, William E. Evans, Mary V. Relling, Jun J. Yang, Paul G. Thomas, John E. Dick, Roland P. Kuiper and Charles G. Mullighan

Blood Cancer Discov July 1 2020 1 (1) 96-111; DOI:10.1158/0008-5472.BCD-19-0041

The landscape of mutations and clonal evolution trajectories in pediatric ALL reveal relapse-fated, drug-resistant subclones present at diagnosis and expanded by therapy.
Research Articles

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia

Shinobu Tsuzuki, Takahiko Yasuda, Shinya Kojima, Masahito Kawazu, Koshi Akahane, Takeshi Inukai, Masue Imaizumi, Takanobu Morishita, Koichi Miyamura, Toshihide Ueno, Sivasundaram Karnan, Akinobu Ota, Toshinori Hyodo, Hiroyuki Konishi, Masashi Sanada, Hirokazu Nagai, Keizo Horibe, Akihiro Tomita, Kyogo Suzuki, Hideki Muramatsu, Yoshiyuki Takahashi, Yasushi Miyazaki, Itaru Matsumura, Hitoshi Kiyoi, Yoshitaka Hosokawa, Hiroyuki Mano and Fumihiko Hayakawa

Blood Cancer Discov July 1 2020 1 (1) 82-95; DOI:10.1158/2643-3230.BCD-19-0080

MEFD2 fusion protein reprograms B-ALL transcriptional circuits, establishing selfreinforcing regulatory network dependent on pre-BCR and SREBF1, which can be exploited to therapeutically target a fusion-driven leukemia.
Research Articles

Genomic Characterization of HIV-Associated Plasmablastic Lymphoma Identifies Pervasive Mutations in the JAK–STAT Pathway

Zhaoqi Liu, Ioan Filip, Karen Gomez, Dewaldt Engelbrecht, Shabnum Meer, Pooja N. Lalloo, Pareen Patel, Yvonne Perner, Junfei Zhao, Jiguang Wang, Laura Pasqualucci, Raul Rabadan and Pascale Willem

Blood Cancer Discov July 1 2020 1 (1) 112-125; DOI:10.1158/2643-3230.BCD-20-0051

Jak-STAT, Ras, Notch pathway genes and CD44 are frequently mutated in HIV-associated PBL, and together with transcriptomic features distinguish the disease from closely related B-cell cancers.
Research Articles

Monosomic Loss of MIR15A/MIR16-1 Is a Driver of Multiple Myeloma Proliferation and Disease Progression

Marta Chesi, Caleb K. Stein, Victoria M. Garbitt, Meaghen E. Sharik, Yan W. Asmann, Matteo Bergsagel, Daniel L. Riggs, Seth J. Welsh, Erin W. Meermeier, Shaji K. Kumar, Esteban Braggio and P. Leif Bergsagel

Blood Cancer Discov July 1 2020 1 (1) 68-81; DOI:10.1158/0008-5472.BCD-19-0068

MIR15A/MIR16-1 deletion promotes multiple myeloma (MM) initiation and progression in mice, identifying it as a key tumor suppressor gene associated with human chromosome 13 loss in MM.
Research Articles | Free Article

Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on MIR300 Antiproliferative and PP2A-Activating Functions

Giovannino Silvestri, Rossana Trotta, Lorenzo Stramucci, Justin J. Ellis, Jason G. Harb, Paolo Neviani, Shuzhen Wang, Ann-Kathrin Eisfeld, Christopher J. Walker, Bin Zhang, Klara Srutova, Carlo Gambacorti-Passerini, Gabriel Pineda, Catriona H. M. Jamieson, Fabio Stagno, Paolo Vigneri, Georgios Nteliopoulos, Philippa C. May, Alistair G. Reid, Ramiro Garzon, Denis-Claude Roy, Moutuaata M. Moutuou, Martin Guimond, Peter Hokland, Michael W. Deininger, Garrett Fitzgerald, Christopher Harman, Francesco Dazzi, Dragana Milojkovic, Jane F. Apperley, Guido Marcucci, Jianfei Qi, Katerina Machova Polakova, Ying Zou, Xiaoxuan Fan, Maria R. Baer, Bruno Calabretta and Danilo Perrotti

Blood Cancer Discov July 1 2020 1 (1) 48-67; DOI:10.1158/0008-5472.BCD-19-0039

Differential regulation of MIR300 targets by TUG1 lncRNA promotes CML leukemic progenitor survival while retaining cell cycle arrest, and blocking MIR300-TUG1 interaction eliminates quiescent leukemic stem cells.